Pre-Clinical Evaluation

During drug discovery and pre-clinical development, it is essential to have multiple mechanism-related readouts that predict successful clinical outcomes. This segment of research at VVP provides key information that bridges the gap between experimental and clinical results. Some activities in this area include:

Development and optimization of high-throughput screening strategies for small molecule inhibitors

Ex vivo human vessel segment perfusion model for identification of adhesion modulators
In vitro cell viability and apoptosis assays for chemo-resistance and enhanced chemo-uptake

Ex ovo chick chorioallantoic membrane (CAM) system for angiogenesis and tumorigenesis modulators

Mouse tumor xenograft model for evaluating novel targeted cancer therapeutics and combination therapies

In vitro screening of anti-thrombotic, anti-platelet and thrombolytic agents